Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects

Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the commercial LOPAC®Pfizer library on aphidicolin-induce...

Descripción completa

Detalles Bibliográficos
Autores principales: Raffaele, Marco, Kovacovicova, Kristina, Biagini, Tommaso, Lo Re, Oriana, Frohlich, Jan, Giallongo, Sebastiano, Nhan, James D., Giannone, Antonino Giulio, Cabibi, Daniela, Ivanov, Martin, Tonchev, Anton B., Mistrik, Martin, Lacey, Matthew, Dzubak, Petr, Gurska, Sona, Hajduch, Marian, Bartek, Jiri, Mazza, Tommaso, Micale, Vincenzo, Curran, Sean P., Vinciguerra, Manlio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612119/
https://www.ncbi.nlm.nih.gov/pubmed/34820764
http://dx.doi.org/10.1007/s11357-021-00487-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612119/
https://www.ncbi.nlm.nih.gov/pubmed/34820764
http://dx.doi.org/10.1007/s11357-021-00487-y

Ejemplares similares