Total synthesis of nahuoic acid A via a putative biogenetic intramolecular Diels–Alder (IMDA) reaction

Inspired by the biogenetic proposal of an intramolecular Diels–Alder (IMDA) cycloaddition, the total synthesis of natural product nahuoic acid A, a cofactor-competitive inhibitor of the epigenetic enzyme lysine methyl transferase SETD8, has been carried out. A non-conjugated pentaenal precursor was...

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Detalles Bibliográficos
Autores principales: Guillade, Lucía, Mora, Paula, Villar, Pedro, Alvarez, Rosana, R. de Lera, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612404/
https://www.ncbi.nlm.nih.gov/pubmed/34909158
http://dx.doi.org/10.1039/d1sc04524e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612404/
https://www.ncbi.nlm.nih.gov/pubmed/34909158
http://dx.doi.org/10.1039/d1sc04524e

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