Cargando…

Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis

Imbalance between osteoblasts and osteoclasts accounts for the incidence and deterioration of postmenopausal osteoporosis. Abnormally elevated RANKL and TNF-α levels after menopause promote osteoclast formation and inhibit osteoblast differentiation, respectively. Here, nanodecoys capable of scaveng...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Yang, Deng, Yekun, Liu, Zhongmin, Yin, Mengyuan, Hou, Mengying, Zhao, Ziyin, Zhou, Xiaozhong, Yin, Lichen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612675/ https://www.ncbi.nlm.nih.gov/pubmed/34818042 http://dx.doi.org/10.1126/sciadv.abl6432

Ejemplares similares

Human PBMC scRNA-seq–based aging clocks reveal ribosome to inflammation balance as a single-cell aging hallmark and super longevity
por: Zhu, Hongming, et al.
Publicado: (2023)

A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
por: Shi, Chengxin, et al.
Publicado: (2022)

Suppression of osteoclast multinucleation via a posttranscriptional regulation–based spatiotemporally selective delivery system
por: Wang, Qingqing, et al.
Publicado: (2022)

The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts
por: Liu, Huadie, et al.
Publicado: (2023)

Rational polyelectrolyte nanoparticles endow preosteoclast-targeted siRNA transfection for anabolic therapy of osteoporosis
por: Zhang, Zheng, et al.
Publicado: (2023)

Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment
por: Liu, Xueliang, et al.
Publicado: (2023)

A balanced Oct4 interactome is crucial for maintaining pluripotency
por: Han, Dong, et al.
Publicado: (2022)

Biointerface mineralization generates ultraresistant gut microbes as oral biotherapeutics
por: Geng, Zhongmin, et al.
Publicado: (2023)

Chronic intermittent hypobaric hypoxia ameliorates osteoporosis after spinal cord injury through balancing osteoblast and osteoclast activities in rats
por: Zhang, Li, et al.
Publicado: (2023)

NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice
por: Zhang, Peipei, et al.
Publicado: (2021)

S-Adenosylmethionine–responsive cystathionine β-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis
por: Bandyopadhyay, Parijat, et al.
Publicado: (2022)

A balance of noncanonical Semaphorin signaling from the cerebrospinal fluid regulates apical cell dynamics during corticogenesis
por: Gerstmann, Katrin, et al.
Publicado: (2022)

The temporal balance between self-renewal and differentiation of human neural stem cells requires the amyloid precursor protein
por: Shabani, Khadijeh, et al.
Publicado: (2023)

Cell membrane-derived biomimetic nanodecoys for viruses
por: Liu, Xuan, et al.
Publicado: (2020)

A far-red light–inducible CRISPR-Cas12a platform for remote-controlled genome editing and gene activation
por: Wang, Xinyi, et al.
Publicado: (2021)

Tet2 coordinates with Foxo1 and Runx1 to balance T follicular helper cell and T helper 1 cell differentiation
por: Baessler, Andrew, et al.
Publicado: (2022)

TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection
por: Wu, Yongjian, et al.
Publicado: (2021)

A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine–related JAK-STAT signal
por: Chen, Chengjuan, et al.
Publicado: (2022)

Na, K-ATPase α1 cooperates with its endogenous ligand to reprogram immune microenvironment of lung carcinoma and promotes immune escape
por: Yang, Kaiyong, et al.
Publicado: (2023)

Radiogenomic-based multiomic analysis reveals imaging intratumor heterogeneity phenotypes and therapeutic targets
por: Su, Guan-Hua, et al.
Publicado: (2023)

Molecular architecture regulation for the design of instant and robust underwater adhesives
por: Yu, Jing, et al.
Publicado: (2023)

Screening diagnostic markers of osteoporosis based on ferroptosis of osteoblast and osteoclast
por: Cao, Zhihai, et al.
Publicado: (2023)

Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4
por: Guo, Qiqi, et al.
Publicado: (2022)

Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain binding
por: Xu, Xiaolong, et al.
Publicado: (2023)

Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets
por: Han, Yi, et al.
Publicado: (2023)

Spinal cord tissue engineering via covalent interaction between biomaterials and cells
por: Liu, Weiyuan, et al.
Publicado: (2023)

In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancer
por: Ji, Peng, et al.
Publicado: (2022)

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation
por: Qiu, Min, et al.
Publicado: (2023)

Twin-bioengine self-adaptive micro/nanorobots using enzyme actuation and macrophage relay for gastrointestinal inflammation therapy
por: Zhang, Baozhen, et al.
Publicado: (2023)

Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions
por: Christie, Shaun M., et al.
Publicado: (2022)

RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes
por: Ma, Hui, et al.
Publicado: (2022)

The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression
por: Yang, Han, et al.
Publicado: (2022)

Distinct roles of ORAI1 in T cell–mediated allergic airway inflammation and immunity to influenza A virus infection
por: Wang, Yin-Hu, et al.
Publicado: (2022)

Impaired osteoblast and osteoclast function characterize the osteoporosis of Snyder - Robinson syndrome
por: Albert, Jessica S, et al.
Publicado: (2015)

The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
por: Xu, Jie, et al.
Publicado: (2023)

Ethylene modulates translation dynamics in Arabidopsis under submergence via GCN2 and EIN2
por: Cho, Hsing-Yi, et al.
Publicado: (2022)

Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes
por: Xu, Chang, et al.
Publicado: (2021)

Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target
por: Shi, Jiandong, et al.
Publicado: (2023)

Fungal-fungal cocultivation leads to widespread secondary metabolite alteration requiring the partial loss-of-function VeA1 protein
por: Wang, Gang, et al.
Publicado: (2022)

Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
por: Liu, Liu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ham590f19kq1chpitllfortt0g