The 40S-LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity

Ribosomes execute the transcriptional program in every cell. Critical to sustain nearly all cellular activities, ribosome biogenesis requires the translation of ~200 factors of which 80 are ribosomal proteins (RPs). As ribosome synthesis depends on RP mRNA translation, a priority within the translat...

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Detalles Bibliográficos
Autores principales: Fuentes, Pedro, Pelletier, Joffrey, Martinez-Herráez, Carolina, Diez-Obrero, Virginia, Iannizzotto, Flavia, Rubio, Teresa, Garcia-Cajide, Marta, Menoyo, Sandra, Moreno, Victor, Salazar, Ramón, Tauler, Albert, Gentilella, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612684/
https://www.ncbi.nlm.nih.gov/pubmed/34818049
http://dx.doi.org/10.1126/sciadv.abg9275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612684/
https://www.ncbi.nlm.nih.gov/pubmed/34818049
http://dx.doi.org/10.1126/sciadv.abg9275

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