Influence of CYP2D6 Phenotypes on the Pharmacokinetics of Aripiprazole and Dehydro-Aripiprazole Using a Physiologically Based Pharmacokinetic Approach

BACKGROUND AND OBJECTIVES: Aripiprazole is an atypical antipsychotic drug that is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, which mainly form its active metabolite dehydro-aripiprazole. Because of the genetic polymorphism of CYP2D6, plasma concentrations are highly variable between differ...

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Detalles Bibliográficos
Autores principales: Kneller, Lisa Alina, Zubiaur, Pablo, Koller, Dora, Abad-Santos, Francisco, Hempel, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613074/
https://www.ncbi.nlm.nih.gov/pubmed/34125422
http://dx.doi.org/10.1007/s40262-021-01041-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613074/
https://www.ncbi.nlm.nih.gov/pubmed/34125422
http://dx.doi.org/10.1007/s40262-021-01041-x

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