LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade

Exhausted CD8(+) T cells are key targets of immune checkpoint blockade therapy and their ineffective reinvigoration limits the durable benefit in some cancer patients. Here, we demonstrate that histone demethylase LSD1 acts to enforce an epigenetic program in progenitor exhausted CD8(+) T cells to a...

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Detalles Bibliográficos
Autores principales: Liu, Yi, Debo, Brian, Li, Mingfeng, Shi, Zhennan, Sheng, Wanqiang, Shi, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613218/
https://www.ncbi.nlm.nih.gov/pubmed/34819502
http://dx.doi.org/10.1038/s41467-021-27179-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613218/
https://www.ncbi.nlm.nih.gov/pubmed/34819502
http://dx.doi.org/10.1038/s41467-021-27179-7

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