Cargando…

Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion

Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The endosomal system influences how RTK signa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marco, Sergi, Neilson, Matthew, Moore, Madeleine, Perez-Garcia, Arantxa, Hall, Holly, Mitchell, Louise, Lilla, Sergio, Blanco, Giovani R., Hedley, Ann, Zanivan, Sara, Norman, Jim C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613289/ https://www.ncbi.nlm.nih.gov/pubmed/34819513 http://dx.doi.org/10.1038/s41467-021-26839-y

Ejemplares similares

Cyclosporine A inhibits MRTF‐SRF signaling through Na(+)/K(+) ATPase inhibition and actin remodeling
por: Burat, Bastien, et al.
Publicado: (2019)

Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD
por: McNeill, Madeleine C., et al.
Publicado: (2020)

The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression
por: Fernández-Barrera, Jaime, et al.
Publicado: (2018)

MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
por: Liu, Chen-Ying, et al.
Publicado: (2016)

Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway
por: Morimatsu, Maho, et al.
Publicado: (2020)

Regulation of Dendritic Synaptic Morphology and Transcription by the SRF Cofactor MKL/MRTF
por: Tabuchi, Akiko, et al.
Publicado: (2021)

Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations
por: Le Dour, Caroline, et al.
Publicado: (2022)

Actomyosin and the MRTF-SRF pathway downregulate FGFR1 in mesenchymal stromal cells
por: Zonderland, Jip, et al.
Publicado: (2020)

Prevention of bleomycin‐induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway
por: Pawelec, Kendell M., et al.
Publicado: (2022)

Circadian clock control of MRTF/SRF pathway suppresses beige adipocyte thermogenic recruitment
por: Xiong, Xuekai, et al.
Publicado: (2022)

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A
por: Pawłowski, Rafał, et al.
Publicado: (2010)

HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity
por: Zhang, Mengxue, et al.
Publicado: (2018)

Exercise‐dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF‐SRF signalling
por: Solagna, Francesca, et al.
Publicado: (2020)

The nature and intensity of mechanical stimulation drive different dynamics of MRTF-A nuclear redistribution after actin remodeling in myoblasts
por: Montel, Lorraine, et al.
Publicado: (2019)

Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation
por: Kuchler, Oliver, et al.
Publicado: (2022)

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics
por: Foster, Charles T., et al.
Publicado: (2017)

In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis
por: Tagalakis, Aristides D., et al.
Publicado: (2018)

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis
por: Yu-Wai-Man, Cynthia, et al.
Publicado: (2017)

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts
por: Kepser, Lara-Jane, et al.
Publicado: (2021)

A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation
por: Guenther, Carla, et al.
Publicado: (2019)

Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis
por: Afzal, Junaid, et al.
Publicado: (2022)

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
por: Esnault, Cyril, et al.
Publicado: (2014)

Nuclear actin filaments
por: Wells, William A.
Publicado: (2006)

SUMOylation of nuclear actin
por: Hofmann, Wilma A., et al.
Publicado: (2009)

Mutant SRF and YAP1 remodel the chromatin to entice cardiac myocyte nuclear division
por: Marian, Ali J.
Publicado: (2022)

Transcriptional regulation and nuclear reprogramming: roles of nuclear actin and actin-binding proteins
por: Miyamoto, Kei, et al.
Publicado: (2012)

SRF depletion in early life contributes to social interaction deficits in the adulthood
por: Roszkowska, Matylda, et al.
Publicado: (2022)

Nuclear muon capture
por: Mukhopadhyay, N C
Publicado: (1976)

Srf controls satellite cell fusion through the maintenance of actin architecture
por: Randrianarison-Huetz, Voahangy, et al.
Publicado: (2018)

Regulation of fiber-specific actin expression by the Drosophila SRF ortholog Blistered
por: DeAguero, Ashley A., et al.
Publicado: (2019)

RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1
por: Rajakylä, Eeva Kaisa, et al.
Publicado: (2015)

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
por: Horita, Henrick, et al.
Publicado: (2016)

Nuclear actin: to polymerize or not to polymerize
por: Hofmann, Wilma A., et al.
Publicado: (2006)

Differential effects of depleting agents on cytoplasmic and nuclear non-protein sulphydryls: a fluorescence image cytometry study.
por: Thomas, M., et al.
Publicado: (1995)

Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11
por: Riggs, Blake, et al.
Publicado: (2003)

Pulmonary Silicosis Alters MicroRNA Expression in Rat Lung and miR-411-3p Exerts Anti-fibrotic Effects by Inhibiting MRTF-A/SRF Signaling
por: Gao, Xuemin, et al.
Publicado: (2020)

Systematics of nuclear muon capture
por: Kohyama, Y, et al.
Publicado: (1979)

Pion capture and nuclear structure
por: Ericson, Torleif Eric Oskar
Publicado: (1962)

Isomer excitation and depletion in nuclear reactions
por: Oganessian, Yu T, et al.
Publicado: (1996)

Nuclear envelope-associated endosomes deliver surface proteins to the nucleus
por: Chaumet, Alexandre, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_t5lrq5hrij7ogjegukmtmdofe7