Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design

The monosaccharide l-Rhamnose is an important component of bacterial cell walls. The first step in the l-rhamnose biosynthetic pathway is catalysed by glucose-1-phosphate thymidylyltransferase (RmlA), which condenses glucose-1-phosphate (Glu-1-P) with deoxythymidine triphosphate (dTTP) to yield dTDP...

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Detalles Bibliográficos
Autores principales: Xiao, Ganyuan, Alphey, Magnus S., Tran, Fanny, Pirrie, Lisa, Milbeo, Pierre, Zhou, Yi, Bickel, Jasmine K., Kempf, Oxana, Kempf, Karl, Naismith, James H., Westwood, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613358/
https://www.ncbi.nlm.nih.gov/pubmed/34757294
http://dx.doi.org/10.1016/j.bmc.2021.116477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613358/
https://www.ncbi.nlm.nih.gov/pubmed/34757294
http://dx.doi.org/10.1016/j.bmc.2021.116477

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