Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Adeno-associated virus (AAV)-mediated CRISPR-Cas9 editing holds promise to treat many diseases. The immune response to bacterial-derived Cas9 has been speculated as a hurdle for AAV-CRISPR therapy. However, immunological consequences of AAV-mediated Cas9 expression have thus far not been thoroughly...

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Detalles Bibliográficos
Autores principales: Hakim, Chady H., Kumar, Sandeep R. P., Pérez-López, Dennis O., Wasala, Nalinda B., Zhang, Dong, Yue, Yongping, Teixeira, James, Pan, Xiufang, Zhang, Keqing, Million, Emily D., Nelson, Christopher E., Metzger, Samantha, Han, Jin, Louderman, Jacqueline A., Schmidt, Florian, Feng, Feng, Grimm, Dirk, Smith, Bruce F., Yao, Gang, Yang, N. Nora, Gersbach, Charles A., Chen, Shi-jie, Herzog, Roland W., Duan, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613397/
https://www.ncbi.nlm.nih.gov/pubmed/34819506
http://dx.doi.org/10.1038/s41467-021-26830-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613397/
https://www.ncbi.nlm.nih.gov/pubmed/34819506
http://dx.doi.org/10.1038/s41467-021-26830-7

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