Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice

Bistable motoneurons of the spinal cord exhibit warmth-activated plateau potential driven by Na(+) and triggered by a brief excitation. The thermoregulating molecular mechanisms of bistability and their role in motor functions remain unknown. Here, we identify thermosensitive Na(+)-permeable Trpm5 c...

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Detalles Bibliográficos
Autores principales: Bos, Rémi, Drouillas, Benoît, Bouhadfane, Mouloud, Pecchi, Emilie, Trouplin, Virginie, Korogod, Sergiy M., Brocard, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613399/
https://www.ncbi.nlm.nih.gov/pubmed/34819493
http://dx.doi.org/10.1038/s41467-021-27113-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613399/
https://www.ncbi.nlm.nih.gov/pubmed/34819493
http://dx.doi.org/10.1038/s41467-021-27113-x

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