Cargando…
Cleavage by MMP‐13 renders VWF unable to bind to collagen but increases its platelet reactivity
BACKGROUND: Atherosclerotic plaque rupture and subsequent thrombosis underpin thrombotic syndromes. Under inflammatory conditions in the unstable plaque, perturbed endothelial cells secrete von Willebrand Factor (VWF) which, via its interaction with GpIbα, enables platelet rolling across and adheren...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614119/ https://www.ncbi.nlm.nih.gov/pubmed/31894636 http://dx.doi.org/10.1111/jth.14729 |