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Cleavage by MMP‐13 renders VWF unable to bind to collagen but increases its platelet reactivity

BACKGROUND: Atherosclerotic plaque rupture and subsequent thrombosis underpin thrombotic syndromes. Under inflammatory conditions in the unstable plaque, perturbed endothelial cells secrete von Willebrand Factor (VWF) which, via its interaction with GpIbα, enables platelet rolling across and adheren...

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Detalles Bibliográficos
Autores principales: Howes, Joanna‐Marie, Knäuper, Vera, Malcor, Jean‐Daniel, Farndale, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614119/
https://www.ncbi.nlm.nih.gov/pubmed/31894636
http://dx.doi.org/10.1111/jth.14729