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Reverse Ordered Sequential Mechanism for Lactoperoxidase with Inhibition by Hydrogen Peroxide

Lactoperoxidase (LPO, Fe(III) in its resting state in the absence of substrates)—an enzyme secreted from human mammary, salivary, and other mucosal glands—catalyzes the oxidation of thiocyanate (SCN(−)) by hydrogen peroxide (H(2)O(2)) to produce hypothiocyanite (OSCN(−)), which functions as an antim...

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Detalles Bibliográficos
Autores principales: Cupp-Sutton, Kellye, Ashby, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614691/
https://www.ncbi.nlm.nih.gov/pubmed/34829517
http://dx.doi.org/10.3390/antiox10111646