β-Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation

ROS-activated cSrc tyrosine kinase (TK) promotes the degradation of β-dystroglycan (β-DG), a dystrophin-glycoprotein complex component, which may reinforce damaging signals in Duchenne muscular dystrophy (DMD). Therefore, cSrc-TK represents a promising therapeutic target. In mdx mice, a 4-week subcu...

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Detalles Bibliográficos
Autores principales: Mantuano, Paola, Boccanegra, Brigida, Conte, Elena, De Bellis, Michela, Cirmi, Santa, Sanarica, Francesca, Cappellari, Ornella, Arduino, Ilaria, Cutrignelli, Annalisa, Lopedota, Angela Assunta, Mele, Antonietta, Denora, Nunzio, De Luca, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615430/
https://www.ncbi.nlm.nih.gov/pubmed/34827740
http://dx.doi.org/10.3390/biom11111742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615430/
https://www.ncbi.nlm.nih.gov/pubmed/34827740
http://dx.doi.org/10.3390/biom11111742

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