The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites

Cellular homeostasis depends on robust protein quality control (PQC) pathways that discern misfolded proteins from functional ones in the cell. One major branch of PQC involves the controlled degradation of misfolded proteins by the ubiquitin-proteasome system. Here ubiquitin ligases must recognize...

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Detalles Bibliográficos
Autores principales: Ibarra, Rebeca, Borror, Heather R., Hart, Bryce, Gardner, Richard G., Kleiger, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615460/
https://www.ncbi.nlm.nih.gov/pubmed/34827617
http://dx.doi.org/10.3390/biom11111619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615460/
https://www.ncbi.nlm.nih.gov/pubmed/34827617
http://dx.doi.org/10.3390/biom11111619

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