Revealing Topological Barriers against Knot Untying in Thermal and Mechanical Protein Unfolding by Molecular Dynamics Simulations

The knot is one of the most remarkable topological features identified in an increasing number of proteins with important functions. However, little is known about how the knot is formed during protein folding, and untied or maintained in protein unfolding. By means of all-atom molecular dynamics si...

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Detalles Bibliográficos
Autores principales: Xu, Yan, Kang, Runshan, Ren, Luyao, Yang, Lin, Yue, Tongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615548/
https://www.ncbi.nlm.nih.gov/pubmed/34827686
http://dx.doi.org/10.3390/biom11111688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615548/
https://www.ncbi.nlm.nih.gov/pubmed/34827686
http://dx.doi.org/10.3390/biom11111688

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