Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performe...

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Autores principales: Mazumder, Atiqul Haq, Barnett, Jennifer, Isometsä, Erkki Tapio, Lindberg, Nina, Torniainen-Holm, Minna, Lähteenvuo, Markku, Lahdensuo, Kaisla, Kerkelä, Martta, Ahola-Olli, Ari, Hietala, Jarmo, Kampman, Olli, Kieseppä, Tuula, Jukuri, Tuomas, Häkkinen, Katja, Cederlöf, Erik, Haaki, Willehard, Kajanne, Risto, Wegelius, Asko, Männynsalo, Teemu, Niemi-Pynttäri, Jussi, Suokas, Kimmo, Lönnqvist, Jouko, Tiihonen, Jari, Paunio, Tiina, Vainio, Seppo Juhani, Palotie, Aarno, Niemelä, Solja, Suvisaari, Jaana, Veijola, Juha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615595/
https://www.ncbi.nlm.nih.gov/pubmed/34827421
http://dx.doi.org/10.3390/brainsci11111422
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author Mazumder, Atiqul Haq
Barnett, Jennifer
Isometsä, Erkki Tapio
Lindberg, Nina
Torniainen-Holm, Minna
Lähteenvuo, Markku
Lahdensuo, Kaisla
Kerkelä, Martta
Ahola-Olli, Ari
Hietala, Jarmo
Kampman, Olli
Kieseppä, Tuula
Jukuri, Tuomas
Häkkinen, Katja
Cederlöf, Erik
Haaki, Willehard
Kajanne, Risto
Wegelius, Asko
Männynsalo, Teemu
Niemi-Pynttäri, Jussi
Suokas, Kimmo
Lönnqvist, Jouko
Tiihonen, Jari
Paunio, Tiina
Vainio, Seppo Juhani
Palotie, Aarno
Niemelä, Solja
Suvisaari, Jaana
Veijola, Juha
author_facet Mazumder, Atiqul Haq
Barnett, Jennifer
Isometsä, Erkki Tapio
Lindberg, Nina
Torniainen-Holm, Minna
Lähteenvuo, Markku
Lahdensuo, Kaisla
Kerkelä, Martta
Ahola-Olli, Ari
Hietala, Jarmo
Kampman, Olli
Kieseppä, Tuula
Jukuri, Tuomas
Häkkinen, Katja
Cederlöf, Erik
Haaki, Willehard
Kajanne, Risto
Wegelius, Asko
Männynsalo, Teemu
Niemi-Pynttäri, Jussi
Suokas, Kimmo
Lönnqvist, Jouko
Tiihonen, Jari
Paunio, Tiina
Vainio, Seppo Juhani
Palotie, Aarno
Niemelä, Solja
Suvisaari, Jaana
Veijola, Juha
author_sort Mazumder, Atiqul Haq
collection PubMed
description The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
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spelling pubmed-86155952021-11-26 Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder Mazumder, Atiqul Haq Barnett, Jennifer Isometsä, Erkki Tapio Lindberg, Nina Torniainen-Holm, Minna Lähteenvuo, Markku Lahdensuo, Kaisla Kerkelä, Martta Ahola-Olli, Ari Hietala, Jarmo Kampman, Olli Kieseppä, Tuula Jukuri, Tuomas Häkkinen, Katja Cederlöf, Erik Haaki, Willehard Kajanne, Risto Wegelius, Asko Männynsalo, Teemu Niemi-Pynttäri, Jussi Suokas, Kimmo Lönnqvist, Jouko Tiihonen, Jari Paunio, Tiina Vainio, Seppo Juhani Palotie, Aarno Niemelä, Solja Suvisaari, Jaana Veijola, Juha Brain Sci Article The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder. MDPI 2021-10-27 /pmc/articles/PMC8615595/ /pubmed/34827421 http://dx.doi.org/10.3390/brainsci11111422 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mazumder, Atiqul Haq
Barnett, Jennifer
Isometsä, Erkki Tapio
Lindberg, Nina
Torniainen-Holm, Minna
Lähteenvuo, Markku
Lahdensuo, Kaisla
Kerkelä, Martta
Ahola-Olli, Ari
Hietala, Jarmo
Kampman, Olli
Kieseppä, Tuula
Jukuri, Tuomas
Häkkinen, Katja
Cederlöf, Erik
Haaki, Willehard
Kajanne, Risto
Wegelius, Asko
Männynsalo, Teemu
Niemi-Pynttäri, Jussi
Suokas, Kimmo
Lönnqvist, Jouko
Tiihonen, Jari
Paunio, Tiina
Vainio, Seppo Juhani
Palotie, Aarno
Niemelä, Solja
Suvisaari, Jaana
Veijola, Juha
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
title Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
title_full Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
title_fullStr Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
title_full_unstemmed Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
title_short Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
title_sort reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective disorder and bipolar disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615595/
https://www.ncbi.nlm.nih.gov/pubmed/34827421
http://dx.doi.org/10.3390/brainsci11111422
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