Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performe...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615595/ https://www.ncbi.nlm.nih.gov/pubmed/34827421 http://dx.doi.org/10.3390/brainsci11111422 |
_version_ | 1784604142313930752 |
---|---|
author | Mazumder, Atiqul Haq Barnett, Jennifer Isometsä, Erkki Tapio Lindberg, Nina Torniainen-Holm, Minna Lähteenvuo, Markku Lahdensuo, Kaisla Kerkelä, Martta Ahola-Olli, Ari Hietala, Jarmo Kampman, Olli Kieseppä, Tuula Jukuri, Tuomas Häkkinen, Katja Cederlöf, Erik Haaki, Willehard Kajanne, Risto Wegelius, Asko Männynsalo, Teemu Niemi-Pynttäri, Jussi Suokas, Kimmo Lönnqvist, Jouko Tiihonen, Jari Paunio, Tiina Vainio, Seppo Juhani Palotie, Aarno Niemelä, Solja Suvisaari, Jaana Veijola, Juha |
author_facet | Mazumder, Atiqul Haq Barnett, Jennifer Isometsä, Erkki Tapio Lindberg, Nina Torniainen-Holm, Minna Lähteenvuo, Markku Lahdensuo, Kaisla Kerkelä, Martta Ahola-Olli, Ari Hietala, Jarmo Kampman, Olli Kieseppä, Tuula Jukuri, Tuomas Häkkinen, Katja Cederlöf, Erik Haaki, Willehard Kajanne, Risto Wegelius, Asko Männynsalo, Teemu Niemi-Pynttäri, Jussi Suokas, Kimmo Lönnqvist, Jouko Tiihonen, Jari Paunio, Tiina Vainio, Seppo Juhani Palotie, Aarno Niemelä, Solja Suvisaari, Jaana Veijola, Juha |
author_sort | Mazumder, Atiqul Haq |
collection | PubMed |
description | The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder. |
format | Online Article Text |
id | pubmed-8615595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86155952021-11-26 Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder Mazumder, Atiqul Haq Barnett, Jennifer Isometsä, Erkki Tapio Lindberg, Nina Torniainen-Holm, Minna Lähteenvuo, Markku Lahdensuo, Kaisla Kerkelä, Martta Ahola-Olli, Ari Hietala, Jarmo Kampman, Olli Kieseppä, Tuula Jukuri, Tuomas Häkkinen, Katja Cederlöf, Erik Haaki, Willehard Kajanne, Risto Wegelius, Asko Männynsalo, Teemu Niemi-Pynttäri, Jussi Suokas, Kimmo Lönnqvist, Jouko Tiihonen, Jari Paunio, Tiina Vainio, Seppo Juhani Palotie, Aarno Niemelä, Solja Suvisaari, Jaana Veijola, Juha Brain Sci Article The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder. MDPI 2021-10-27 /pmc/articles/PMC8615595/ /pubmed/34827421 http://dx.doi.org/10.3390/brainsci11111422 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mazumder, Atiqul Haq Barnett, Jennifer Isometsä, Erkki Tapio Lindberg, Nina Torniainen-Holm, Minna Lähteenvuo, Markku Lahdensuo, Kaisla Kerkelä, Martta Ahola-Olli, Ari Hietala, Jarmo Kampman, Olli Kieseppä, Tuula Jukuri, Tuomas Häkkinen, Katja Cederlöf, Erik Haaki, Willehard Kajanne, Risto Wegelius, Asko Männynsalo, Teemu Niemi-Pynttäri, Jussi Suokas, Kimmo Lönnqvist, Jouko Tiihonen, Jari Paunio, Tiina Vainio, Seppo Juhani Palotie, Aarno Niemelä, Solja Suvisaari, Jaana Veijola, Juha Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
title | Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
title_full | Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
title_fullStr | Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
title_full_unstemmed | Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
title_short | Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder |
title_sort | reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective disorder and bipolar disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615595/ https://www.ncbi.nlm.nih.gov/pubmed/34827421 http://dx.doi.org/10.3390/brainsci11111422 |
work_keys_str_mv | AT mazumderatiqulhaq reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT barnettjennifer reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT isometsaerkkitapio reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT lindbergnina reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT torniainenholmminna reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT lahteenvuomarkku reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT lahdensuokaisla reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT kerkelamartta reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT aholaolliari reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT hietalajarmo reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT kampmanolli reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT kieseppatuula reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT jukurituomas reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT hakkinenkatja reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT cederloferik reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT haakiwillehard reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT kajanneristo reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT wegeliusasko reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT mannynsaloteemu reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT niemipynttarijussi reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT suokaskimmo reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT lonnqvistjouko reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT tiihonenjari reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT pauniotiina reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT vainioseppojuhani reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT palotieaarno reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT niemelasolja reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT suvisaarijaana reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder AT veijolajuha reactiontimeandvisualmemoryinconnectiontohazardousdrinkingpolygenicscoresinschizophreniaschizoaffectivedisorderandbipolardisorder |