The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models

Animal models of Parkinson’s disease, in which the human α-synuclein transgene is overexpressed in the nigrostriatal pathway using viral vectors, are widely considered to be the most relevant models of the human condition. However, although highly valid, these models have major limitations related t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kelly, Rachel, Cairns, Andrew G., Ådén, Jörgen, Almqvist, Fredrik, Bemelmans, Alexis-Pierre, Brouillet, Emmanuel, Patton, Tommy, McKernan, Declan P., Dowd, Eilís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615715/
https://www.ncbi.nlm.nih.gov/pubmed/34827685
http://dx.doi.org/10.3390/biom11111685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615715/
https://www.ncbi.nlm.nih.gov/pubmed/34827685
http://dx.doi.org/10.3390/biom11111685

Ejemplares similares