Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study

Mesenchymal glioblastoma stem cells (GSCs), a subpopulation in glioblastoma that are responsible for therapy resistance and tumor spreading in the brain, reportedly upregulate aldehyde dehydrogenase isoform-1A3 (ALDH1A3) which can be inhibited by disulfiram (DSF), an FDA-approved drug formerly presc...

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Detalles Bibliográficos
Autores principales: Zirjacks, Lisa, Stransky, Nicolai, Klumpp, Lukas, Prause, Lukas, Eckert, Franziska, Zips, Daniel, Schleicher, Sabine, Handgretinger, Rupert, Huber, Stephan M., Ganser, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615869/
https://www.ncbi.nlm.nih.gov/pubmed/34827559
http://dx.doi.org/10.3390/biom11111561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615869/
https://www.ncbi.nlm.nih.gov/pubmed/34827559
http://dx.doi.org/10.3390/biom11111561

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