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Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegener...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615936/ https://www.ncbi.nlm.nih.gov/pubmed/34829854 http://dx.doi.org/10.3390/biomedicines9111625 |
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author | Magalhães, João Duarte Fão, Lígia Vilaça, Rita Cardoso, Sandra Morais Rego, Ana Cristina |
author_facet | Magalhães, João Duarte Fão, Lígia Vilaça, Rita Cardoso, Sandra Morais Rego, Ana Cristina |
author_sort | Magalhães, João Duarte |
collection | PubMed |
description | Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegenerative diseases. There are several lines of evidence that associate protein misfolding and mitochondrial dysfunction in the etiology of Alzheimer’s, Parkinson’s, and Huntington’s diseases. Macroautophagy has been implicated in the degradation of different protein aggregates such as Aβ, tau, alpha-synuclein (α-syn), and mutant huntingtin (mHtt) and in the clearance of dysfunctional mitochondria. Taking these into consideration, targeting autophagy might represent an effective therapeutic strategy to eliminate protein aggregates and to improve mitochondrial function in these disorders. The present review describes our current understanding on the role of macroautophagy in neurodegenerative disorders and focuses on possible strategies for its therapeutic modulation. |
format | Online Article Text |
id | pubmed-8615936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86159362021-11-26 Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions Magalhães, João Duarte Fão, Lígia Vilaça, Rita Cardoso, Sandra Morais Rego, Ana Cristina Biomedicines Review Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegenerative diseases. There are several lines of evidence that associate protein misfolding and mitochondrial dysfunction in the etiology of Alzheimer’s, Parkinson’s, and Huntington’s diseases. Macroautophagy has been implicated in the degradation of different protein aggregates such as Aβ, tau, alpha-synuclein (α-syn), and mutant huntingtin (mHtt) and in the clearance of dysfunctional mitochondria. Taking these into consideration, targeting autophagy might represent an effective therapeutic strategy to eliminate protein aggregates and to improve mitochondrial function in these disorders. The present review describes our current understanding on the role of macroautophagy in neurodegenerative disorders and focuses on possible strategies for its therapeutic modulation. MDPI 2021-11-05 /pmc/articles/PMC8615936/ /pubmed/34829854 http://dx.doi.org/10.3390/biomedicines9111625 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Magalhães, João Duarte Fão, Lígia Vilaça, Rita Cardoso, Sandra Morais Rego, Ana Cristina Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions |
title | Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions |
title_full | Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions |
title_fullStr | Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions |
title_full_unstemmed | Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions |
title_short | Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions |
title_sort | macroautophagy and mitophagy in neurodegenerative disorders: focus on therapeutic interventions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615936/ https://www.ncbi.nlm.nih.gov/pubmed/34829854 http://dx.doi.org/10.3390/biomedicines9111625 |
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