Heat Shock Proteins HSPA1 and HSP90AA1 Are Upregulated in Colorectal Polyps and Can Be Targeted in Cancer Cells by Anti-Inflammatory Oxicams with Arylpiperazine Pharmacophore and Benzoyl Moiety Substitutions at Thiazine Ring

Heat shock proteins HSPA1/Hsp70α and HSP90AA1/Hsp90α are crucial for cancer growth but their expression pattern in colorectal polyps or whether they can be modulated by oxicams is unknown. We quantified (RTqPCR) HSPA1 and HSP90AA1 expression in 50 polyp-normal pairs in relation to polyp malignancy p...

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Detalles Bibliográficos
Autores principales: Szczuka, Izabela, Wierzbicki, Jarosław, Serek, Paweł, Szczęśniak-Sięga, Berenika M., Krzystek-Korpacka, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615942/
https://www.ncbi.nlm.nih.gov/pubmed/34827586
http://dx.doi.org/10.3390/biom11111588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615942/
https://www.ncbi.nlm.nih.gov/pubmed/34827586
http://dx.doi.org/10.3390/biom11111588

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