Biological Effects of BET Inhibition by OTX015 (MK-8628) and JQ1 in NPM1-Mutated (NPM1c) Acute Myeloid Leukemia (AML)

BET inhibitors (BETi) including OTX015 (MK-8628) and JQ1 demonstrated antileukemic activity including NPM1c AML cells. Nevertheless, the biological consequences of BETi in NPM1c AML were not fully investigated. Even if of better prognosis AML patients with NPM1c may relapse and treatment remains dif...

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Detalles Bibliográficos
Autores principales: Djamai, Hanane, Berrou, Jeannig, Dupont, Mélanie, Coudé, Marie-Magdelaine, Delord, Marc, Clappier, Emmanuelle, Marceau-Renaut, Alice, Kaci, Anna, Raffoux, Emmanuel, Itzykson, Raphaël, Berthier, Caroline, Wu, Hsin-Chieh, Hleihel, Rita, Bazarbachi, Ali, de Thé, Hugues, Baruchel, André, Gardin, Claude, Dombret, Hervé, Braun, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615962/
https://www.ncbi.nlm.nih.gov/pubmed/34829934
http://dx.doi.org/10.3390/biomedicines9111704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615962/
https://www.ncbi.nlm.nih.gov/pubmed/34829934
http://dx.doi.org/10.3390/biomedicines9111704

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