The Pseudo-Symmetric N-benzyl Hydroxyethylamine Core in a New Series of Heteroarylcarboxyamide HIV-1 Pr Inhibitors: Synthesis, Molecular Modeling and Biological Evaluation

Here, we report the synthesis, enzyme inhibition and structure–activity relationship studies of a new potent class of HIV-1 protease inhibitors, which contain a pseudo-symmetric hydroxyethylamine core and heteroarylcarboxyamide moieties. The simple synthetic pathway furnished nine compounds in a few...

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Detalles Bibliográficos
Autores principales: D’Orsi, Rosarita, Funicello, Maria, Laurita, Teresa, Lupattelli, Paolo, Berti, Federico, Chiummiento, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615997/
https://www.ncbi.nlm.nih.gov/pubmed/34827582
http://dx.doi.org/10.3390/biom11111584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615997/
https://www.ncbi.nlm.nih.gov/pubmed/34827582
http://dx.doi.org/10.3390/biom11111584

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