Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with available treatments only marginally slowing progression or improving survival. A hexanucleotide repeat expansion mutation in the C9ORF72 gene is the most commonly known genetic cause of both sporadic and f...

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Detalles Bibliográficos
Autores principales: Ramic, Melina, Andrade, Nadja S., Rybin, Matthew J., Esanov, Rustam, Wahlestedt, Claes, Benatar, Michael, Zeier, Zane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616043/
https://www.ncbi.nlm.nih.gov/pubmed/34827542
http://dx.doi.org/10.3390/brainsci11111543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616043/
https://www.ncbi.nlm.nih.gov/pubmed/34827542
http://dx.doi.org/10.3390/brainsci11111543

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