Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme

The accumulation of amyloid β-protein (Aβ) is one of the major pathological hallmarks of Alzheimer’s disease. Insulin-degrading enzyme (IDE), a zinc-metalloprotease, is a key enzyme involved in Aβ degradation, which, in addition to Aβ production, is critical for Aβ homeostasis. Here, we demonstrate...

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Detalles Bibliográficos
Autores principales: Mett, Janine, Lauer, Anna A., Janitschke, Daniel, Griebsch, Lea V., Theiss, Elena L., Grimm, Heike S., Koivisto, Hennariikka, Tanila, Heikki, Hartmann, Tobias, Grimm, Marcus O. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616162/
https://www.ncbi.nlm.nih.gov/pubmed/34831163
http://dx.doi.org/10.3390/cells10112941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616162/
https://www.ncbi.nlm.nih.gov/pubmed/34831163
http://dx.doi.org/10.3390/cells10112941

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