Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity

SIMPLE SUMMARY: In this study, we found that the novel small molecule kinase inhibitor DCLK1-IN-1 not only inhibited DCLK1 phosphorylation, stemness, and EMT-related properties of RCC cells but also revealed its potential as an immunotherapy agent and potential combination therapy with anti-PD1 agai...

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Detalles Bibliográficos
Autores principales: Ding, Ling, Yang, Yuning, Ge, Yang, Lu, Qin, Yan, Zixing, Chen, Xuzheng, Du, Jian, Hafizi, Sassan, Xu, Xiaohui, Yao, Jiannan, Liu, Jian, Cao, Zhiyun, Weygant, Nathaniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616267/
https://www.ncbi.nlm.nih.gov/pubmed/34830884
http://dx.doi.org/10.3390/cancers13225729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616267/
https://www.ncbi.nlm.nih.gov/pubmed/34830884
http://dx.doi.org/10.3390/cancers13225729

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