Identification of a Chemotherapeutic Lead Molecule for the Potential Disruption of the FAM72A-UNG2 Interaction to Interfere with Genome Stability, Centromere Formation, and Genome Editing

SIMPLE SUMMARY: Pivotal factors that contribute to tumorigenesis were subjected to analysis by molecular modeling. In particular, the FAM72A-UNG2 protein–protein interaction was modeled to predict a potential solution for the treatment of cancer. We screened chemical libraries to identify withaferin...

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Detalles Bibliográficos
Autores principales: Renganathan, Senthil, Pramanik, Subrata, Ekambaram, Rajasekaran, Kutzner, Arne, Kim, Pok-Son, Heese, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616359/
https://www.ncbi.nlm.nih.gov/pubmed/34831023
http://dx.doi.org/10.3390/cancers13225870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616359/
https://www.ncbi.nlm.nih.gov/pubmed/34831023
http://dx.doi.org/10.3390/cancers13225870

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