Cargando…

Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation

Background. Liver transplantation remains the only viable therapy for liver failure but has a severely restricted utility. Here, we aimed to decellularize rat livers to form acellular 3D bio-scaffolds suitable for seeding with induced pluripotent cells (iPSCs) as a tool to investigate the role of Wn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ebrahim, Nesrine, Badr, Omnia A. M., Yousef, Mohamed M., Hassouna, Amira, Sabry, Dina, Farid, Ayman Samir, Mostafa, Ola, Saihati, Hajir A. Al, Seleem, Yasmin, Abd El Aziz, Eman, Khalil, Ahmed Hassan, Nawar, Ahmed, Shoulah, Ahmed A., Aljasir, Mohammad, Mohamed, Amira Zaki, El-Sherbiny, Mohamed, Elsherbiny, Nehal M., Eladl, Mohamed Ahmed, Forsyth, Nicholas Robert, Salim, Rabab F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616374/ https://www.ncbi.nlm.nih.gov/pubmed/34831042 http://dx.doi.org/10.3390/cells10112819

Ejemplares similares

Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway
por: Ebrahim, Nesrine, et al.
Publicado: (2021)

Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway
por: Ebrahim, Nesrine, et al.
Publicado: (2022)

Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells
por: Ebrahim, Nesrine, et al.
Publicado: (2021)

Maxillary Mucormycosis Osteomyelitis in Post COVID-19 Patients: A Series of Fourteen Cases
por: Said Ahmed, Wael M., et al.
Publicado: (2021)

Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells
por: Ahmed, Ebtehal, et al.
Publicado: (2021)

Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression Analysis
por: Elsherbini, Amira M., et al.
Publicado: (2022)

Curcumin Modulates Oxidative Stress, Fibrosis, and Apoptosis in Drug-Resistant Cancer Cell Lines
por: Gabr, Sami A., et al.
Publicado: (2022)

Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats
por: Elkattawy, Hany A., et al.
Publicado: (2022)

Functional and Aesthetic Outcomes of Reconstruction of Soft-Tissue Defects of the Heel with Free Flap
por: Elgohary, Hussein, et al.
Publicado: (2018)

Ultrastructural changes and nestin expression accompanying compensatory renal growth after unilateral nephrectomy in adult rats
por: Eladl, Mohamed Ahmed, et al.
Publicado: (2017)

Glycyrrhizic acid ameliorates submandibular gland oxidative stress, autophagy and vascular dysfunction in rat model of type 1 diabetes
por: Asseri, Saad Mohamed, et al.
Publicado: (2022)

Protective effect of nano vitamin D against fatty degeneration in submandibular and sublingual salivary glands: A histological and ultrastructural study
por: Al-Serwi, Rasha Hamed, et al.
Publicado: (2021)

Oncoplastic Volume Replacement for Breast Cancer: Latissimus Dorsi Flap versus Thoracodorsal Artery Perforator Flap
por: Abdelrahman, Emad M., et al.
Publicado: (2019)

Effect of Losartan in Complete Freund’s Adjuvant –Induced Arthritis in Rats
por: Abdel El- Gaphar, Omnia Ahmed Mohamed, et al.
Publicado: (2018)

Hepatoprotective Effects of Hyaluronic Acid-Preconditioned Bone Marrow Mesenchymal Stem Cells against Liver Toxicity via the Inhibition of Apoptosis and the Wnt/β-Catenin Signaling Pathway
por: Awadalla, Amira, et al.
Publicado: (2023)

Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation
por: El-Sherbiny, Mohamed, et al.
Publicado: (2022)

The Combined Anti-Tumor Efficacy of Bioactive Hydroxyapatite Nanoparticles Loaded with Altretamine
por: Alghazwani, Yahia, et al.
Publicado: (2023)

Sexual Dimorphism Impact on the Ground Reaction Force Acting on the Mediolateral Direction During Level Walking: Hip Abductor Muscle Biomechanics and Its Correlation to GRF Moment Arm
por: Abd-Eltawab, Amany E., et al.
Publicado: (2022)

Memory T Cells Discrepancies in COVID-19 Patients
por: Al Saihati, Hajir A., et al.
Publicado: (2023)

Optimization and In Vitro Characterization of Telmisartan Loaded Sodium Alginate Beads and Its In Vivo Efficacy Investigation in Hypertensive Induced Animal Model
por: Uthumansha, Ubaidulla, et al.
Publicado: (2023)

Clinicopathological Features and Treatment Challenges in Triple Negative Breast Cancer Patients: A Retrospective Cohort Study
por: Elwan, Amira, et al.
Publicado: (2021)

Role of Dapagliflozin and Liraglutide on Diabetes-Induced Cardiomyopathy in Rats: Implication of Oxidative Stress, Inflammation, and Apoptosis
por: El-Shafey, Mohamed, et al.
Publicado: (2022)

Formulation and Characterization of Doxycycline-Loaded Polymeric Nanoparticles for Testing Antitumor/Antiangiogenic Action in Experimental Colon Cancer in Mice
por: Alshaman, Reem, et al.
Publicado: (2022)

Student perception of the effect of problem familiarity on group discussion quality in a problem-based learning environment
por: Abdalla, Mohamed Elhassan, et al.
Publicado: (2019)

Rapamycin Improves Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Renoprotective Effect against Cisplatin-Induced Acute Nephrotoxicity in Rats by Inhibiting the mTOR/AKT Signaling Pathway
por: Awadalla, Amira, et al.
Publicado: (2022)

Leflunomide Induces Dose-Dependent Lung Injury in Mice via Stimulating Vimentin and NLRP3 Inflammasome Production
por: El-Sherbiny, Mohamed, et al.
Publicado: (2021)

Epidemiological and Histopathological Investigation of Sarcocystis spp. in Slaughtered Dromedary Camels (Camelus dromedarius) in Egypt
por: Gareh, Ahmed, et al.
Publicado: (2020)

pKpQIL-like plasmid contributes to the dissemination of bla(NDM-1) and plasmid mediated quinolone resistance determinants among multi drug resistant Klebsiella pneumoniae in Assiut university hospital, Egypt
por: Hammad, Heba Ali, et al.
Publicado: (2023)

Detection and Quantification of Some Ethanol-Producing Bacterial Strains in the Gut of Mouse Model of Non-Alcoholic Fatty Liver Disease: Role of Metformin
por: Abouelkheir, Mohamed, et al.
Publicado: (2023)

Enhancement of Cisplatin Cytotoxicity by Cu(II)–Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma
por: Al-Serwi, Rasha H., et al.
Publicado: (2020)

Crucial Role of PLGA Nanoparticles in Mitigating the Amiodarone-Induced Pulmonary Toxicity
por: Motawea, Amira, et al.
Publicado: (2021)

Single nucleotide polymorphisms in microRNA binding sites on the HOX genes regulate carcinogenesis: An in-silico approach
por: El-Huneidi, Waseem, et al.
Publicado: (2021)

Decellularization and recellularization of the ovary for bioengineering applications; studies in the mouse
por: Alshaikh, Ahmed Baker, et al.
Publicado: (2020)

High Degradation of Methylene Blue Using a New Nanocomposite Based on Zeolitic Imidazolate Framework-8
por: Abd El Khalk, Amira Ahmed, et al.
Publicado: (2021)

Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
por: El-Sherbiny, Mohamed, et al.
Publicado: (2022)

α-Lipoic Acid Protects against Cyclosporine A-Induced Hepatic Toxicity in Rats: Effect on Oxidative Stress, Inflammation, and Apoptosis
por: El-Mancy, Eman M., et al.
Publicado: (2022)

Correction of pre-existing astigmatism with phacoemulsification using toric intraocular lens versus spherical intraocular lens and wave front guided surface ablation
por: El-Shehawy, Ahmed, et al.
Publicado: (2022)

Possible Underlying Mechanisms for the Renoprotective Effect of Retinoic Acid-Pretreated Wharton’s Jelly Mesenchymal Stem Cells against Renal Ischemia/Reperfusion Injury
por: Barakat, Mai, et al.
Publicado: (2022)

An Ideal Approach for Enhancing 5-Fluorouracil Anticancer Efficacy by Nanoemulsion for Cytotoxicity against a Human Hepatoma Cell Line (HepG2 Cells)
por: Mohamed, Jamal Moideen Muthu, et al.
Publicado: (2022)

Carvacrol-Loaded Phytosomes for Enhanced Wound Healing: Molecular Docking, Formulation, DoE-Aided Optimization, and in vitro/in vivo Evaluation
por: Tafish, Ahmed Mowafy, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bkkkl0etbro5rfb64q4kuhep4s