Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway

The homeostasis of extracellular matrix (ECM) and actin dynamics in the trabecular meshwork (TM) outflow pathway plays a critical role in intraocular pressure (IOP) regulation. We studied the role of cathepsin K (CTSK), a lysosomal cysteine protease and a potent collagenase, on ECM modulation and ac...

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Detalles Bibliográficos
Autores principales: Soundararajan, Avinash, Ghag, Sachin Anil, Vuda, Sai Supriya, Wang, Ting, Pattabiraman, Padmanabhan Paranji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616380/
https://www.ncbi.nlm.nih.gov/pubmed/34831087
http://dx.doi.org/10.3390/cells10112864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616380/
https://www.ncbi.nlm.nih.gov/pubmed/34831087
http://dx.doi.org/10.3390/cells10112864

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