PI3K Pathway Inhibition with NVP-BEZ235 Hinders Glycolytic Metabolism in Glioblastoma Multiforme Cells

Glioblastoma (GBM) is the most lethal primary brain cancer that lacks effective molecular targeted therapies. The PI3K/AKT/mTOR pathway is activated in 90% of all Glioblastoma multiforme (GBM) tumors. To gain insight into the impact of the PI3K pathway on GBM metabolism, we treated U87MG GBM cells w...

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Detalles Bibliográficos
Autores principales: Udawant, Shreya, Litif, Carl, Lopez, Alma, Gunn, Bonnie, Schuenzel, Erin, Keniry, Megan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616488/
https://www.ncbi.nlm.nih.gov/pubmed/34831287
http://dx.doi.org/10.3390/cells10113065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616488/
https://www.ncbi.nlm.nih.gov/pubmed/34831287
http://dx.doi.org/10.3390/cells10113065

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