Synthetic Optimization and MAPK Pathway Activation Anticancer Mechanism of Polyisoprenylated Cysteinyl Amide Inhibitors

SIMPLE SUMMARY: RAS G-protein genes are frequently mutated and drive the progression of about 30% of human cancers. Polyisoprenylated cysteinyl amide inhibitors (PCAIs) offer a novel approach to address the decades-long anti-RAS drug development challenge. This manuscript reports on the continuous d...

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Detalles Bibliográficos
Autores principales: Tawfeeq, Nada, Jin, Yonghao, Lamango, Nazarius S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616522/
https://www.ncbi.nlm.nih.gov/pubmed/34830912
http://dx.doi.org/10.3390/cancers13225757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616522/
https://www.ncbi.nlm.nih.gov/pubmed/34830912
http://dx.doi.org/10.3390/cancers13225757

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