TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responses

TICAM-1 (also called TRIF) is the sole adaptor of TLR3 that recognizes double-stranded RNA. Here, we report that TICAM-1 is involved not only in TLR3 signaling but also in the cytokine receptor IL-17RA signaling. We found that TICAM-1 bound to IL-17R adaptor Act1 to inhibit the interaction between I...

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Detalles Bibliográficos
Autores principales: Miyashita, Yusuke, Kouwaki, Takahisa, Tsukamoto, Hirotake, Okamoto, Masaaki, Nakamura, Kimitoshi, Oshiumi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616538/
https://www.ncbi.nlm.nih.gov/pubmed/34819358
http://dx.doi.org/10.26508/lsa.202101181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616538/
https://www.ncbi.nlm.nih.gov/pubmed/34819358
http://dx.doi.org/10.26508/lsa.202101181

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