Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes

PURPOSE: Iris biological features such as surface features and profile characteristics reflected the development of iris stroma and microvessels. Iris vessels and microcirculation are still lack of effective detection methods, and we can directly observe only the iris surface biological characterist...

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Autores principales: Fu, Lin, Dai, Qi, Zhu, Pengzhi, Jia, Xu, Bao, Fangjun, Chen, Xiaoyu, Fu, Yana, Lian, Hengli, Yang, Weihua, Ye, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616650/
https://www.ncbi.nlm.nih.gov/pubmed/34840631
http://dx.doi.org/10.1155/2021/5866267
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author Fu, Lin
Dai, Qi
Zhu, Pengzhi
Jia, Xu
Bao, Fangjun
Chen, Xiaoyu
Fu, Yana
Lian, Hengli
Yang, Weihua
Ye, Yufeng
author_facet Fu, Lin
Dai, Qi
Zhu, Pengzhi
Jia, Xu
Bao, Fangjun
Chen, Xiaoyu
Fu, Yana
Lian, Hengli
Yang, Weihua
Ye, Yufeng
author_sort Fu, Lin
collection PubMed
description PURPOSE: Iris biological features such as surface features and profile characteristics reflected the development of iris stroma and microvessels. Iris vessels and microcirculation are still lack of effective detection methods, and we can directly observe only the iris surface biological characteristics. This cross-sectional study evaluated the association between iris surface biological features and corneal biomechanics in young adults with myopia. METHODS: We recruited 152 patients with myopia aged ≥18 years, from the Eye Hospital of Wenzhou Medical University, who had complete Corneal Visualization Scheimpflug Technology (Corvis ST) data and graded iris surface features. Iris surface features included crypts, furrows, and color measured from digital slit lamp images. The biomechanical properties of the cornea were assessed using Corvis ST. Only 1 eye of each participant was randomly selected for analysis. Associations between the iris surface features and corneal biomechanics were analyzed using linear regression models. The grade of iris crypts, furrows, and color and corneal biomechanical parameters measured with Corvis ST was the main outcome measures. RESULTS: The iris crypts were significantly associated with deflection amplitude at the first applanation (A1 DLA, β = 0.001, P = 0.013), A1 delta arc length (A1 dArcL) (β = −0.001, P = 0.01), maximum delta arc length (dArcLM) (β = −0.004, P = 0.03), and stiffness at the first applanation (SP-A1) (β = −2.092, P = 0.016). The iris furrows were only associated with integrated radius (β = −0.212, P = 0.025). Iris color was found not related with corneal biomechanical parameters measured via Corvis ST. CONCLUSIONS: Iris surface features were associated with corneal biomechanical properties in myopic eyes; more iris crypts were associated with lower corneal stiffness while more extensive furrows were related with higher corneal stiffness. Iris crypts and furrows may provide useful information on corneal biomechanical properties in myopic eyes.
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spelling pubmed-86166502021-11-26 Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes Fu, Lin Dai, Qi Zhu, Pengzhi Jia, Xu Bao, Fangjun Chen, Xiaoyu Fu, Yana Lian, Hengli Yang, Weihua Ye, Yufeng Dis Markers Research Article PURPOSE: Iris biological features such as surface features and profile characteristics reflected the development of iris stroma and microvessels. Iris vessels and microcirculation are still lack of effective detection methods, and we can directly observe only the iris surface biological characteristics. This cross-sectional study evaluated the association between iris surface biological features and corneal biomechanics in young adults with myopia. METHODS: We recruited 152 patients with myopia aged ≥18 years, from the Eye Hospital of Wenzhou Medical University, who had complete Corneal Visualization Scheimpflug Technology (Corvis ST) data and graded iris surface features. Iris surface features included crypts, furrows, and color measured from digital slit lamp images. The biomechanical properties of the cornea were assessed using Corvis ST. Only 1 eye of each participant was randomly selected for analysis. Associations between the iris surface features and corneal biomechanics were analyzed using linear regression models. The grade of iris crypts, furrows, and color and corneal biomechanical parameters measured with Corvis ST was the main outcome measures. RESULTS: The iris crypts were significantly associated with deflection amplitude at the first applanation (A1 DLA, β = 0.001, P = 0.013), A1 delta arc length (A1 dArcL) (β = −0.001, P = 0.01), maximum delta arc length (dArcLM) (β = −0.004, P = 0.03), and stiffness at the first applanation (SP-A1) (β = −2.092, P = 0.016). The iris furrows were only associated with integrated radius (β = −0.212, P = 0.025). Iris color was found not related with corneal biomechanical parameters measured via Corvis ST. CONCLUSIONS: Iris surface features were associated with corneal biomechanical properties in myopic eyes; more iris crypts were associated with lower corneal stiffness while more extensive furrows were related with higher corneal stiffness. Iris crypts and furrows may provide useful information on corneal biomechanical properties in myopic eyes. Hindawi 2021-11-18 /pmc/articles/PMC8616650/ /pubmed/34840631 http://dx.doi.org/10.1155/2021/5866267 Text en Copyright © 2021 Lin Fu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fu, Lin
Dai, Qi
Zhu, Pengzhi
Jia, Xu
Bao, Fangjun
Chen, Xiaoyu
Fu, Yana
Lian, Hengli
Yang, Weihua
Ye, Yufeng
Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_full Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_fullStr Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_full_unstemmed Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_short Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes
title_sort association between iris biological features and corneal biomechanics in myopic eyes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616650/
https://www.ncbi.nlm.nih.gov/pubmed/34840631
http://dx.doi.org/10.1155/2021/5866267
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