Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication

3CLpro is a key proteinase for SARS-CoV-2 replication and serves as an important target for antiviral drug development. However, how its activity is regulated intracellularly is still obscure. In this study, we developed a 3CLpro protease activity reporter system to examine the impact of various fac...

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Detalles Bibliográficos
Autores principales: Du, Liubing, Xie, Yanchun, Zheng, Kai, Wang, Niu, Gao, Mingcheng, Yu, Ting, Cao, Liu, Shao, QianQian, Zou, Yong, Xia, Wei, Fang, Qianglin, Zhao, Bo, Guo, Deyin, Peng, Xiaoxue, Pan, Ji-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616692/
https://www.ncbi.nlm.nih.gov/pubmed/34847508
http://dx.doi.org/10.1016/j.redox.2021.102199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616692/
https://www.ncbi.nlm.nih.gov/pubmed/34847508
http://dx.doi.org/10.1016/j.redox.2021.102199

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