Gene editing enables rapid engineering of complex antibiotic assembly lines

Re-engineering biosynthetic assembly lines, including nonribosomal peptide synthetases (NRPS) and related megasynthase enzymes, is a powerful route to new antibiotics and other bioactive natural products that are too complex for chemical synthesis. However, engineering megasynthases is very challeng...

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Detalles Bibliográficos
Autores principales: Thong, Wei Li, Zhang, Yingxin, Zhuo, Ying, Robins, Katherine J., Fyans, Joanna K., Herbert, Abigail J., Law, Brian J. C., Micklefield, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616955/
https://www.ncbi.nlm.nih.gov/pubmed/34824225
http://dx.doi.org/10.1038/s41467-021-27139-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616955/
https://www.ncbi.nlm.nih.gov/pubmed/34824225
http://dx.doi.org/10.1038/s41467-021-27139-1

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