Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

Membrane proteins are essential for cellular growth, signalling and homeostasis, making up a large proportion of therapeutic targets. However, the necessity for a solubilising agent to extract them from the membrane creates challenges in their structural and functional study. Although amphipols have...

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Detalles Bibliográficos
Autores principales: Higgins, Anna J., Flynn, Alex J., Marconnet, Anaïs, Musgrove, Laura J., Postis, Vincent L. G., Lippiat, Jonathan D., Chung, Chun-wa, Ceska, Tom, Zoonens, Manuela, Sobott, Frank, Muench, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617058/
https://www.ncbi.nlm.nih.gov/pubmed/34824357
http://dx.doi.org/10.1038/s42003-021-02834-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617058/
https://www.ncbi.nlm.nih.gov/pubmed/34824357
http://dx.doi.org/10.1038/s42003-021-02834-3

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