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Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis
Membrane proteins are essential for cellular growth, signalling and homeostasis, making up a large proportion of therapeutic targets. However, the necessity for a solubilising agent to extract them from the membrane creates challenges in their structural and functional study. Although amphipols have...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617058/ https://www.ncbi.nlm.nih.gov/pubmed/34824357 http://dx.doi.org/10.1038/s42003-021-02834-3 |