Cargando…

Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy

Gastrointestinal mucositis is a complication of anticancer treatment, with few validated in vitro systems suitable to study the complex mechanisms of mucosal injury. Therefore, we aimed to develop and characterize a chemotherapeutic-induced model of mucositis using 3D intestinal organoids. Organoids...

Descripción completa

Detalles Bibliográficos
Autores principales:	da Silva Ferreira, A. R., van der Aa, S. A. J., Wehkamp, T., Wardill, H. R., ten Klooster, J. P., Garssen, J., Harthoorn, L. F., Hartog, A., Harmsen, H. J. M., Tissing, W. J. E., van Bergenhenegouwen, J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617074/ https://www.ncbi.nlm.nih.gov/pubmed/34824316 http://dx.doi.org/10.1038/s41598-021-02308-w

Ejemplares similares

Prophylactic Treatment with Vitamins C and B2 for Methotrexate-Induced Gastrointestinal Mucositis
por: da Silva Ferreira, Ana Rita, et al.
Publicado: (2020)

Pre-therapy fasting slows epithelial turnover and modulates the microbiota but fails to mitigate methotrexate-induced gastrointestinal mucositis
por: Wardill, H. R., et al.
Publicado: (2020)

Pitfalls and novel experimental approaches to optimize microbial interventions for chemotherapy-induced gastrointestinal mucositis
por: da Silva Ferreira, Ana R., et al.
Publicado: (2020)

Does Chemotherapy-Induced Gastrointestinal Mucositis Affect the Bioavailability and Efficacy of Anti-Infective Drugs?
por: da Silva Ferreira, Ana Rita, et al.
Publicado: (2021)

Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia
por: Oosterom, Natanja, et al.
Publicado: (2018)

Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model
por: Kuiken, Nicoline S. S., et al.
Publicado: (2015)

The Role of Intestinal Microbiota in the Development and Severity of Chemotherapy-Induced Mucositis
por: van Vliet, Michel J., et al.
Publicado: (2010)

Riboflavin Supplementation Promotes Butyrate Production in the Absence of Gross Compositional Changes in the Gut Microbiota
por: Liu, Lei, et al.
Publicado: (2023)

Whey-based diet containing medium chain triglycerides modulates the gut microbiota and protects the intestinal mucosa from chemotherapy while maintaining therapy efficacy
por: Wardill, Hannah R., et al.
Publicado: (2023)

A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia
por: Oosterom, N., et al.
Publicado: (2018)

A free amino acid‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey
por: van Sadelhoff, Joris H. J., et al.
Publicado: (2020)

Exposure of anti-infective drugs and the dynamic changes of the gut microbiota during gastrointestinal mucositis in autologous stem cell transplant patients: a pilot study
por: Märtson, Anne-Grete, et al.
Publicado: (2023)

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
por: van Sadelhoff, Joris H. J., et al.
Publicado: (2019)

Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever
por: Wardill, H. R., et al.
Publicado: (2021)

Lipoproteins attenuate TLR2 and TLR4 activation by bacteria and bacterial ligands with differences in affinity and kinetics
por: van Bergenhenegouwen, Jeroen, et al.
Publicado: (2016)

Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow's Milk Allergic Mice
por: Vonk, Marlotte M., et al.
Publicado: (2019)

Supporting the gastrointestinal microenvironment during high-dose chemotherapy and stem cell transplantation by inhibiting IL-1 signaling with anakinra
por: Wardill, H. R., et al.
Publicado: (2022)

Butyrate and propionate restore interleukin 13‐compromised esophageal epithelial barrier function
por: Kleuskens, Mirelle T.A., et al.
Publicado: (2021)

The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies
por: Wiertsema, Selma P., et al.
Publicado: (2021)

IL-33 Is Involved in the Anti-Inflammatory Effects of Butyrate and Propionate on TNFα-Activated Endothelial Cells
por: Li, Meng, et al.
Publicado: (2021)

Biomarkers and non-invasive tests for gastrointestinal mucositis
por: Kuiken, N. S. S., et al.
Publicado: (2017)

Butyrate and hexanoate-enriched triglycerides increase postprandrial systemic butyrate and hexanoate in men with overweight/obesity: A double-blind placebo-controlled randomized crossover trial
por: van Deuren, Thirza, et al.
Publicado: (2023)

Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Response to an Elemental Diet
por: Warners, Marijn J, et al.
Publicado: (2017)

Butyrate and Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation
por: Cushing, Kelly, et al.
Publicado: (2015)

Butyrate and Propionate Restore the Cytokine and House Dust Mite Compromised Barrier Function of Human Bronchial Airway Epithelial Cells
por: Richards, Levi B., et al.
Publicado: (2020)

Butyrate Protects Barrier Integrity and Suppresses Immune Activation in a Caco-2/PBMC Co-Culture Model While HDAC Inhibition Mimics Butyrate in Restoring Cytokine-Induced Barrier Disruption
por: Korsten, Sandra G. P. J., et al.
Publicado: (2023)

From Pathogenesis to Intervention: The Importance of the Microbiome in Oral Mucositis
por: Bruno, Julia S., et al.
Publicado: (2023)

In Vitro Evidence for Immune-Modulatory Properties of Non-Digestible Oligosaccharides: Direct Effect on Human Monocyte Derived Dendritic Cells
por: Lehmann, Sarah, et al.
Publicado: (2015)

The Gut Microbiota as a Therapeutic Target in IBD and Metabolic Disease: A Role for the Bile Acid Receptors FXR and TGR5
por: Baars, Annemarie, et al.
Publicado: (2015)

Methotrexate-induced mucositis with extra-mucosal involvement after acidental overdose
por: Rampon, Greice, et al.
Publicado: (2018)

Oral-Gut Microbiome Axis in the Pathogenesis of Cancer Treatment-Induced Oral Mucositis
por: Al-Qadami, Ghanyah, et al.
Publicado: (2022)

Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation
por: Madella, Avra Melina, et al.
Publicado: (2022)

Feeding strategies in pediatric cancer patients with gastrointestinal mucositis: a multicenter prospective observational study and international survey
por: Kuiken, Nicoline S.S., et al.
Publicado: (2017)

Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error
por: Amissah-Arthur, Maame-Boatemaa, et al.
Publicado: (2020)

Human Milk Oligosaccharide 2′-Fucosyllactose Inhibits Ligand Binding to C-Type Lectin DC-SIGN but Not to Langerin
por: Mukherjee, Reshmi, et al.
Publicado: (2022)

Butyrate limits human natural killer cell effector function
por: Zaiatz-Bittencourt, Vanessa, et al.
Publicado: (2023)

Butyrate Ameliorates Insufficient Sleep-Induced Intestinal Mucosal Damage in Humans and Mice
por: Gao, Ting, et al.
Publicado: (2022)

Early-Life Nutritional Factors and Mucosal Immunity in the Development of Autoimmune Diabetes
por: Xiao, Ling, et al.
Publicado: (2017)

Measuring everyday functional competence using the Rasch assessment of everyday activity limitations (REAL) item bank
por: Oude Voshaar, Martijn A. H., et al.
Publicado: (2017)

Cytenamide–butyric acid (1/1)
por: Johnston, Andrea, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_lnl566grv25rjkfiefkh4v7ee8