Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma cause...

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Prif Awduron: Álvarez, Eva G., Demeulemeester, Jonas, Otero, Paula, Jolly, Clemency, García-Souto, Daniel, Pequeño-Valtierra, Ana, Zamora, Jorge, Tojo, Marta, Temes, Javier, Baez-Ortega, Adrian, Rodriguez-Martin, Bernardo, Oitaben, Ana, Bruzos, Alicia L., Martínez-Fernández, Mónica, Haase, Kerstin, Zumalave, Sonia, Abal, Rosanna, Rodríguez-Castro, Jorge, Rodriguez-Casanova, Aitor, Diaz-Lagares, Angel, Li, Yilong, Raine, Keiran M., Butler, Adam P., Otero, Iago, Ono, Atsushi, Aikata, Hiroshi, Chayama, Kazuaki, Ueno, Masaki, Hayami, Shinya, Yamaue, Hiroki, Maejima, Kazuhiro, Blanco, Miguel G., Forns, Xavier, Rivas, Carmen, Ruiz-Bañobre, Juan, Pérez-del-Pulgar, Sofía, Torres-Ruiz, Raúl, Rodriguez-Perales, Sandra, Garaigorta, Urtzi, Campbell, Peter J., Nakagawa, Hidewaki, Van Loo, Peter, Tubio, Jose M. C.
Fformat: Online Erthygl Texto
Iaith:English
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617174/
https://www.ncbi.nlm.nih.gov/pubmed/34824211
http://dx.doi.org/10.1038/s41467-021-26805-8

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617174/
https://www.ncbi.nlm.nih.gov/pubmed/34824211
http://dx.doi.org/10.1038/s41467-021-26805-8

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