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N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization

Synthesis of iron-sulfur (Fe/S) clusters in living cells requires scaffold proteins for both facile synthesis and subsequent transfer of clusters to target apoproteins. The human mitochondrial ISCU2 scaffold protein is part of the core ISC (iron-sulfur cluster assembly) complex that synthesizes a br...

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Detalles Bibliográficos
Autores principales: Freibert, Sven-A., Boniecki, Michal T., Stümpfig, Claudia, Schulz, Vinzent, Krapoth, Nils, Winge, Dennis R., Mühlenhoff, Ulrich, Stehling, Oliver, Cygler, Miroslaw, Lill, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617193/
https://www.ncbi.nlm.nih.gov/pubmed/34824239
http://dx.doi.org/10.1038/s41467-021-27122-w