Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS-induced cancer phenotypes

Oncogenic Ras mutations are highly prevalent in hematopoietic malignancies. However, it is difficult to directly target oncogenic RAS proteins for therapeutic intervention. We have developed a Drosophila acute myeloid leukemia model induced by human KRAS(G12V), which exhibits a dramatic increase in...

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Detalles Bibliográficos
Autores principales: Zhu, Jun-yi, Huang, Xiaohu, Fu, Yulong, Wang, Yin, Zheng, Pan, Liu, Yang, Han, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617310/
https://www.ncbi.nlm.nih.gov/pubmed/34580712
http://dx.doi.org/10.1242/dmm.048953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617310/
https://www.ncbi.nlm.nih.gov/pubmed/34580712
http://dx.doi.org/10.1242/dmm.048953

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