MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

Costello syndrome (CS) is a congenital disorder caused by heterozygous activating germline HRAS mutations in the canonical Ras/mitogen-activated protein kinase (Ras/MAPK) pathway. CS is one of the RASopathies, a large group of syndromes caused by mutations within various components of the Ras/MAPK p...

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Detalles Bibliográficos
Autores principales: Tidyman, William E., Goodwin, Alice F., Maeda, Yoshiko, Klein, Ophir D., Rauen, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617311/
https://www.ncbi.nlm.nih.gov/pubmed/34553752
http://dx.doi.org/10.1242/dmm.049166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617311/
https://www.ncbi.nlm.nih.gov/pubmed/34553752
http://dx.doi.org/10.1242/dmm.049166

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