Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation

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The SARS-CoV-2 coronavirus responsible for the global pandemic contains a novel furin cleavage site in the spike protein (S) that increases viral infectivity and syncytia formation in cells. Here, we show that O-glycosylation near the furin cleavage site is mediated by members of the GALNT enzyme fa...

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Detalles Bibliográficos
Autores principales: Zhang, Liping, Mann, Matthew, Syed, Zulfeqhar A., Reynolds, Hayley M., Tian, E., Samara, Nadine L., Zeldin, Darryl C., Tabak, Lawrence A., Ten Hagen, Kelly G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617502/
https://www.ncbi.nlm.nih.gov/pubmed/34732583
http://dx.doi.org/10.1073/pnas.2109905118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617502/
https://www.ncbi.nlm.nih.gov/pubmed/34732583
http://dx.doi.org/10.1073/pnas.2109905118

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