With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension

Small molecule inhibition of with no lysine kinase 1 (WNK1) (WNK463) signaling activates adenosine monophosphate-activated protein kinase signaling and mitigates membrane enrichment of glucose transporters 1 and 4, which decreases protein O-GlcNAcylation and glycation. Quantitative proteomics of rig...

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Detalles Bibliográficos
Autores principales: Prisco, Sasha Z., Eklund, Megan, Raveendran, Rashmi, Thenappan, Thenappan, Prins, Kurt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617575/
https://www.ncbi.nlm.nih.gov/pubmed/34869947
http://dx.doi.org/10.1016/j.jacbts.2021.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617575/
https://www.ncbi.nlm.nih.gov/pubmed/34869947
http://dx.doi.org/10.1016/j.jacbts.2021.09.004

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