Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions

Controlled polypeptide synthesis via α-amino acid N-carboxylic anhydride (NCA) polymerization using conventional primary amine initiators encounters two major obstacles: (i) normal amine mechanism (NAM) and activated monomer mechanism (AMM) coexist due to amine basicity and nucleophilicity and (ii)...

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Detalles Bibliográficos
Autores principales: Li, Lei, Cen, Jie, Pan, Wenhao, Zhang, Yuben, Leng, Xuanxi, Tan, Zhengqi, Yin, Hao, Liu, Shiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617576/
https://www.ncbi.nlm.nih.gov/pubmed/34877538
http://dx.doi.org/10.34133/2021/9826046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617576/
https://www.ncbi.nlm.nih.gov/pubmed/34877538
http://dx.doi.org/10.34133/2021/9826046

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