Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering

Cardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which...

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Autores principales: Sun, Peng, Zhao, Liang, Zhang, Nanhai, Zhou, Jingxuan, Zhang, Liebing, Wu, Wei, Ji, Baoping, Zhou, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617782/
https://www.ncbi.nlm.nih.gov/pubmed/34828946
http://dx.doi.org/10.3390/foods10112666
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author Sun, Peng
Zhao, Liang
Zhang, Nanhai
Zhou, Jingxuan
Zhang, Liebing
Wu, Wei
Ji, Baoping
Zhou, Feng
author_facet Sun, Peng
Zhao, Liang
Zhang, Nanhai
Zhou, Jingxuan
Zhang, Liebing
Wu, Wei
Ji, Baoping
Zhou, Feng
author_sort Sun, Peng
collection PubMed
description Cardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which targeted different metabolism pathways. However, some therapies also caused various adverse effects. Thus, there is a need for new treatment options and/or combination therapies to inhibit the LDL-C level. Dietary polyphenols have received much attention in the prevention of cardiovascular diseases due to their potential LDL-C lowering effects. However, the effectiveness and potential mechanisms of polyphenols in lowering LDL-C is not comprehensively summarized. This review focused on dietary polyphenols that could reduce LDL-C and their mechanisms of action. This review also discussed the limitations and suggestions regarding previous studies.
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spelling pubmed-86177822021-11-27 Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering Sun, Peng Zhao, Liang Zhang, Nanhai Zhou, Jingxuan Zhang, Liebing Wu, Wei Ji, Baoping Zhou, Feng Foods Review Cardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which targeted different metabolism pathways. However, some therapies also caused various adverse effects. Thus, there is a need for new treatment options and/or combination therapies to inhibit the LDL-C level. Dietary polyphenols have received much attention in the prevention of cardiovascular diseases due to their potential LDL-C lowering effects. However, the effectiveness and potential mechanisms of polyphenols in lowering LDL-C is not comprehensively summarized. This review focused on dietary polyphenols that could reduce LDL-C and their mechanisms of action. This review also discussed the limitations and suggestions regarding previous studies. MDPI 2021-11-02 /pmc/articles/PMC8617782/ /pubmed/34828946 http://dx.doi.org/10.3390/foods10112666 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Peng
Zhao, Liang
Zhang, Nanhai
Zhou, Jingxuan
Zhang, Liebing
Wu, Wei
Ji, Baoping
Zhou, Feng
Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_full Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_fullStr Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_full_unstemmed Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_short Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_sort bioactivity of dietary polyphenols: the role in ldl-c lowering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617782/
https://www.ncbi.nlm.nih.gov/pubmed/34828946
http://dx.doi.org/10.3390/foods10112666
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