Chemoenzymatic Synthesis and Antibody Binding of HIV-1 V1/V2 Glycopeptide-Bacteriophage Qβ Conjugates as a Vaccine Candidate

The broadly neutralizing antibody PG9 recognizes a unique glycopeptide epitope in the V1V2 domain of HIV-1 gp120 envelope glycoprotein. The present study describes the design, synthesis, and antibody-binding analysis of HIV-1 V1V2 glycopeptide-Qβ conjugates as a mimic of the proposed neutralizing ep...

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Detalles Bibliográficos
Autores principales: Zong, Guanghui, Toonstra, Christian, Yang, Qiang, Zhang, Roushu, Wang, Lai-Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617853/
https://www.ncbi.nlm.nih.gov/pubmed/34830420
http://dx.doi.org/10.3390/ijms222212538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617853/
https://www.ncbi.nlm.nih.gov/pubmed/34830420
http://dx.doi.org/10.3390/ijms222212538

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