In Silico Structure-Guided Optimization and Molecular Simulation Studies of 3-Phenoxy-4-(3-trifluoromethylphenyl)pyridazines as Potent Phytoene Desaturase Inhibitors

A series of novel 3-phenoxy-4-(3-trifluoromethylphenyl)pyridazines 2–5 were designed, based on the structure of our previous lead compound 1 through the in silico structure-guided optimization approach. The results showed that some of these new compounds showed a good herbicidal activity at the rate...

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Detalles Bibliográficos
Autores principales: Yang, Lijun, Wang, Dawei, Ma, Dejun, Zhang, Di, Zhou, Nuo, Wang, Jing, Xu, Han, Xi, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618034/
https://www.ncbi.nlm.nih.gov/pubmed/34834071
http://dx.doi.org/10.3390/molecules26226979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618034/
https://www.ncbi.nlm.nih.gov/pubmed/34834071
http://dx.doi.org/10.3390/molecules26226979

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