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In Silico Structure-Guided Optimization and Molecular Simulation Studies of 3-Phenoxy-4-(3-trifluoromethylphenyl)pyridazines as Potent Phytoene Desaturase Inhibitors

A series of novel 3-phenoxy-4-(3-trifluoromethylphenyl)pyridazines 2–5 were designed, based on the structure of our previous lead compound 1 through the in silico structure-guided optimization approach. The results showed that some of these new compounds showed a good herbicidal activity at the rate...

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Detalles Bibliográficos
Autores principales:	Yang, Lijun, Wang, Dawei, Ma, Dejun, Zhang, Di, Zhou, Nuo, Wang, Jing, Xu, Han, Xi, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618034/ https://www.ncbi.nlm.nih.gov/pubmed/34834071 http://dx.doi.org/10.3390/molecules26226979

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