Trisomy of Human Chromosome 21 Orthologs Mapping to Mouse Chromosome 10 Cause Age and Sex-Specific Learning Differences: Relevance to Down Syndrome

Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is the most common genetic cause of intellectual disability. The Dp10(1)Yey (Dp10) is a mouse model of DS that is trisomic for orthologs of 25% of the Hsa21 protein-coding genes, the entirety of the Hsa21 syntenic region on mouse chromosome...

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Detalles Bibliográficos
Autores principales: Minter, Ross, Gardiner, Katheleen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618694/
https://www.ncbi.nlm.nih.gov/pubmed/34828303
http://dx.doi.org/10.3390/genes12111697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618694/
https://www.ncbi.nlm.nih.gov/pubmed/34828303
http://dx.doi.org/10.3390/genes12111697

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