Cargando…
Microbial Efflux Pump Inhibitors: A Journey around Quinoline and Indole Derivatives
Antimicrobial resistance (AMR) is a complex threat to human health and, to date, it represents a hot topic in drug discovery. The use of non-antibiotic molecules to block resistance mechanisms is a powerful alternative to the identification of new antibiotics. Bacterial efflux pumps exert the early...
Autores principales: | Cernicchi, Giada, Felicetti, Tommaso, Sabatini, Stefano |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618814/ https://www.ncbi.nlm.nih.gov/pubmed/34834098 http://dx.doi.org/10.3390/molecules26226996 |
Ejemplares similares
-
Inhibition of Staphylococcus pseudintermedius Efflux Pumps by Using Staphylococcus aureus NorA Efflux Pump Inhibitors
por: Rampacci, Elisa, et al.
Publicado: (2023) -
From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search
por: Cedraro, Nicholas, et al.
Publicado: (2021) -
Biofunctionalization of Poly(lactide-co-glycolic acid) Using Potent NorA Efflux Pump Inhibitors Immobilized on Nanometric Alpha-Zirconium Phosphate to Reduce Biofilm Formation
por: Pica, Monica, et al.
Publicado: (2021) -
Fighting Antimicrobial
Resistance: Insights on How
the Staphylococcus aureus NorA Efflux Pump Recognizes
2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics
(SuMD) and Molecular Docking Simulations
por: Palazzotti, Deborah, et al.
Publicado: (2023) -
Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics Approach
por: Palazzotti, Deborah, et al.
Publicado: (2019)